Semaglutide Injection Site Reactions: What You Need to Know

By Weight Loss NP, LLC

As a Nurse Practitioners specializing in GLP-1 medications, weight loss, and metabolism, we often address questions about semaglutide injection site reactions. At our medical weight loss practice, Weight Loss NP, LLC (www.theWLNP.com), we help patients navigate the benefits and side effects of weight loss medications, including managing injection site discomfort.

Can Semaglutide Cause Burning at the Injection Site?

It can – Burning at the injection site is a common experience for many patients. While it can be uncomfortable, it is not necessarily a cause for concern. However, because burning and redness can mimic symptoms of an allergic reaction or infection, it’s important to discuss any issues with your healthcare provider.

How Common Are Semaglutide Injection Site Reactions?

In clinical trials, only 1.4% of participants reported injection site reactions, suggesting they are relatively uncommon. However, in my professional experience, I’d estimate the percentage closer to 5% of people experience mild site reactions.

It’s important to note that an injection site reaction does not necessarily mean you are allergic to the medication. Most reactions are mild and resolve on their own, but always consult your provider to rule out more serious issues.

What Causes Semaglutide Injection Site Reactions?

There are a few key reasons why some people experience burning, redness, or swelling at the injection site:

1. Sensitivity to Medication or the Needle

Everyone’s body reacts differently to foreign substances, including medication and even the needle itself. People with more sensitive skin or immune responses are more prone to mild site reactions.

2. Injection Technique

How you administer your injection matters. If the needle is inserted too superficially (just under the skin instead of into the fatty tissue), it can cause more irritation. The adipose (fat) layer has fewer nerves than the skin’s surface, so deeper injections tend to be less painful and cause fewer reactions.

3. Site Overuse

Repeating injections in the same location can cause irritation, scarring, increased sensitivity, and even reduced medication absorption over time. To minimize these issues, you should rotate injection sites—even if you always use your abdomen, make sure to change the exact spot each time.

Common Semaglutide Injection Site Reactions

Aside from burning, patients may experience:

• Redness
• Itching
• Swelling
• Mild discomfort

These symptoms typically resolve within 1-2 hours. If they persist or worsen, contact your healthcare provider.

When Should You Be Concerned?

Rare but more serious reactions include:

• Swelling, itching, redness, and burning lasting more than a few hours
• Symptoms worsening with each injection
• Severe pain at the injection site
• Full body rash or hives
• Other symptoms at time of injection including diffuse swelling, full body itching, immediate onset nausea or vomiting.

If you experience any of these symptoms, seek urgent medical attention to rule out infection or an allergic reaction.

How to Reduce Semaglutide Injection Site Reactions

Here are some proven tips to reduce irritation and discomfort from a GLP-1 injection site reaction:

1. Adjust Your Injection Angle

One of the most effective ways to prevent site reactions is ensuring proper injection technique.

• Instead of injecting at 30-45 degrees, try adjusting to a 60 or 90-degree angle for better absorption into the fat layer.

2. Use Over-the-Counter Treatments

After injecting, you can apply:

• Topical hydrocortisone (to reduce inflammation)
• Topical Benadryl (to minimize itching and irritation)

Both of these are available without a prescription and can help manage minor site reactions effectively.

Final Thoughts: Managing Injection Site Reactions

While semaglutide injection site reactions can be uncomfortable, they are usually mild and manageable. Most people tolerate the medication well, and simple adjustments in technique or site rotation can significantly reduce irritation.

If you have concerns about injection site reactions or want expert guidance on your weight loss journey, visit us at www.theWLNP.com. We’re here to help you achieve sustainable weight loss with personalized, science-backed support!