GLP-1 Medications and Hair Loss: What You Need to Know

By Weight Loss NP, LLC

As Nurse Practitioners specializing in GLP-1 medications, weight loss, and metabolism, we frequently address concerns about potential side effects, including hair loss. At our medical weight loss practice, Weight Loss NP, LLC (www.theWLNP.com), we stay up to date on the latest research to help our patients make informed decisions about their health.

GLP-1 Medications and Their Growing Popularity

GLP-1 medications have surged in popularity over the past few years, with millions of people now using them for conditions such as diabetes, obesity, heart disease, and sleep apnea. With increased usage comes more data on potential side effects—one of which is hair loss.

A recent study (medRxiv study) examined hair loss in nearly 2,000 semaglutide users compared to 1,400 users of bupropion-naltrexone (Contrave), a non-GLP-1 weight loss medication. Here’s what the study found:

Key Findings from the Study

• Overall, hair loss risk with semaglutide was not statistically significant.
  
• In women specifically, the study found a statistically significant difference, with a twofold increased risk of hair loss in semaglutide users compared to bupropion-naltrexone users.
  
• The overall incidence of hair loss was low: Clinical trials have shown that hair loss occurred in 3.3% of semaglutide users compared to 1.4% in a placebo group, meaning that 96.7% of women on semaglutide will not experience hair loss.
  

Why Does Hair Loss Occur on GLP-1 Medications?

In my practice, I’ve observed that 3-5% of patients experience increased hair loss while taking GLP-1 medications. The study suggests that hair loss may be linked to:

• Rapid weight loss (more than 2 lbs per week)
  
• Reduced nutrient availability
  

Patients who lose weight too quickly are more likely to experience hair shedding. This aligns with general knowledge about telogen effluvium, a temporary hair loss condition triggered by significant weight loss or stress on the body.

How to Reduce Hair Loss Risk While on GLP-1s

The good news is that there are steps you can take to minimize your risk of hair loss while using semaglutide or similar medications:

• Lose weight at a steady, medically appropriate rate (0.5-2 lbs per week)
  
• Prioritize nutrient-dense foods, particularly protein and vegetables
  
• Take a high-quality multivitamin daily to fill potential nutrient gaps
  

Will Hair Grow Back After Stopping GLP-1 Medications?

Yes! Hair typically regrows after stopping the medication, and many patients notice regrowth once their weight loss stabilizes.

Effective Treatment for GLP-1-Related Hair Loss

One option we’ve found helpful in our practice is low-dose oral minoxidil, which has shown promising results in reducing hair shedding. Patients often report a decrease in hair loss within a few weeks and visible regrowth within 2-3 months. We offer low-dose oral minoxidil treatment at Weight Loss NP- reach out for information!

Final Thoughts: Is the Risk of Hair Loss Worth It?

While hair loss can be concerning, the overall risk is low (3.3%). Given the significant health benefits of GLP-1 medications—such as weight loss, improved metabolic health, and reduced risk of diabetes and heart disease—the benefits often outweigh this small risk. However, every patient should discuss their concerns with a medical provider to determine the best treatment plan for their needs.

If you’d like to learn more about GLP-1 medications and personalized weight loss strategies, visit us at www.theWLNP.com. We’re here to help you achieve sustainable, healthy weight loss with expert guidance!